Leveraging of NK cell therapeutics for NPC

- by Dr. Lim Chwee Ming

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Abstract: 

NK cells are innate lymphocytes responsible for eliminating virally transformed/mutated cells. In NPC, we have observed that NK cells are infiltrated into the NPC microenvironment which has prognostic significance. Additionally, with advances in cell therapy developments, generating large quantities of highly activated NK cells is feasible on a clinical scale. Using K562 as feeder cells and a cocktail of cytokines, robust expansion of NK cells can be manufactured for clinical translation. In this talk, I will discuss our team’s development of NK cells therapeutics in both refractory and advanced NPC. I will also discuss how this treatment can be integrated into the current standard of care treatment of advanced NPC.